Endocrine Abstracts

Background: Diabetic ketoacidosis (DKA) is a complication of Diabetes Mellitus and is a life-threatening medical emergency usually requiring admission to an intensive care unit. There is no established guideline regarding timing of initiation of oral/enteral feeding in DKA patients.Purpose: To determine if there is a difference in clinical outcomes for DKA patients whose oral/enteral feeding was started early vs patients whose feeding was started beyond ...

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon severe systemic hypersensitivity drug reaction. Several studies have described the occurrence of newly developed endocrine autoimmune diseases following DRESS syndrome resolution. However, little attention has been paid by endocrinologists to this disorder. Here, we report a case of a patient with Graves’ disease following DRESS syndrome.Clinical case: ...

Background: Tuberculosis rarely leads to clinically significant hypercalcemia. However, elderly patients remain predisposed due to advanced age, multiple comorbidities and polypharmacy.Clinical Case: An 81-year-old female presented with 1 month history of bilateral weak hand grip and sluggish mastication. She was initially managed as progressive Parkinson’s Disease. After 3 weeks, she was now reported to have episodes of fall from imbalance. After f...

A 24-year-old woman presented at 33 weeks gestation with severe left-sided abdominal pain and orthopnoea. Ventilation-perfusion scan demonstrated two segmental mismatched defects consistent with bilateral pulmonary embolism. Anticoagulation with enoxaparin was commenced. MRI abdomen, carried out in view of abdominal pain, revealed a 4.5 cm left adrenal mass containing a fluid level. Appearances were in keeping with acute left adrenal haemorrhage. Imp...

A 24-year-old woman presented at 33 weeks gestation with severe left-sided abdominal pain and orthopnoea. Ventilation-perfusion scan demonstrated two segmental mismatched defects consistent with bilateral pulmonary embolism. Anticoagulation with enoxaparin was commenced. MRI abdomen, carried out in view of abdominal pain, revealed a 4.5 cm left adrenal mass containing a fluid level. Appearances were in keeping with acute left adrenal haemorrhage. Imp...

Introduction: The pandemic resulted in changes in delivery of healthcare. Most children and young people (CYP) present with symptoms of T1D for the first time to primary care. Delayed diagnosis is common and associated with risk of life-threatening diabetic ketoacidosis (DKA). In Cardiff, we had a pre-pandemic QI project to improve early diagnosis of T1D. We escalated responses, introduced initiatives to facilitate early diagnosis.Aim: To develop effecti...

Background: Chordomas are rare, invasive and slow growing bone tumours with different locations. Parasellar chordomas are even more rare and the initial manifestations include visual and/or neurological symptoms. In addition, endocrine dysfunction may be present. We describe 4 cases of parasellar chordomas.Clinical cases: 1) Female, 55-years-old, reported headache associated with restriction of left eye movement for the past 3 months. Brain magnetic reso...

The conducted national screening of Bulgarian pregnant women showed a frequency of Hyperglycemia among them of 14.4%. It is known that a number of factors have a significant impact on this disorder. The aim: to assess risk factors for the development of Hyperglycemia in pregnant women in Bulgaria.Material: We screened 547 pregnant women, mean age 30.49±5.12 years, divided into two groups: up to 24 gestational week –g.w. (n-386, 70.6%) and after 2...

Background: We used Mendelian randomization and machine learning (gradient boosting) to assess the causal association of Type 2 Diabetes with osteoporosis.Methods: We selected 155 SNPs associated with type 2 diabetes and glycaemic and insulin-related traits reported in previous studies (1,2) and studied the association with Heel bone mineral density (BMD)) (n= 4 72 996) and risk of fragility fractures (26 157 cases and 17 807 controls) in UKBiob...

G2, P1, IUGR in previous pregnancy. Presented in 34/40 of pregnancy with profound lethargy, muscle weakness and fatigue. Found to have normotensive hypokalaemia − 2.6 mmol/l and mild metabolic alkalosis. No preceding vomiting, diarrhoea or nutritional cause. Pre-natal blood results were not available but reported low K+ in 2009. Required intravenous potassium replacement and symptoms improved dramatically with restoring normokalaemia. Results at diagnosis: K+ ...